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Collaborative Research

To perform multidisciplinary science it is indispensible to collaborate with experts in different fields of research.

One of the main objectives of this network is precisely to facilitate the interaction and collaboration of scientists that would otherwise work independently as they belong to different fields. The exchange of ideas and knowledge between members of the network will be promoted through the organisation of meetings and a specifically developed programme of students mobility between laboratories.

Collaborative Projects

Biochemical, cellular and physiological alterations of the glutamatergic synapse in a trisomic mouse model of Down syndrome

José A. Esteban , Ph.D.

Along this project, we have explored the alterations of the glutamatergic synapse of the Ts65Dn mouse model of Down syndrome. We have fully characterized the proteomic and phosphoproteomic profile of subsynaptic fractions of the hippocampi of [...]

Functional implications of pathogenic mutations in synaptic proteins

Xavier Altafaj , Ph.D.

Most neurodevelopmental disorders (NDDs)have a strong genetic component. Until recently, causal genes had primarily been found in the context of Intellectual Disability [...]

Function of zinc ion (Zn2+) in synaptic biology

Carlos Sindreu , Ph.D.

Homeostasis of ionic or labile zinc (Zn2+) in central neurons and at the synapse might be important in a range of physiological and pathological events. Zn2+ may act as a co-transmitter at certain glutamatergic synapses, participate in neuronal [...]

Role of CBP in the production of MGE-derived interneurons

Angel Barco , Ph.D.

Investigation of the consequences of ablating the CBP encoding gene in interneuron progenitors at the MGE. Behavioral and molecular and cellular biology experiments are conducted in the Barco’s lab. Electrophysiological recordin were conducted in [...]

Identification of layer-specific markers of hippocampal neurons

Liset M de la Prida , Ph.D.

The hippocampus exhibits a huge genetic heterogeneity not only along the septo-temporal axis, but regionally from different subdivisions of CA1, CA2 and CA3 and from deep to superficial locations along the cornu ammonis. These genetic gradients link [...]

Experimental induction of trans-synaptic long-term potentiation

Agnès Gruart Massó , Ph.D.

Since the early 70’s of the past century, long-term potentiation (LTP) evoked experimentally by high-frequency stimulation (HFS) protocols is a popular technique for the study of cellular and molecular mechanisms underlying learning-dependent [...]

Role of dual-specificity phosphatases in hippocampal synaptic plasticity

Juan Lerma , Ph.D.

Ongoing recordings from brain slices of global knockout mice to define possible alterations in synaptic transmission or plasticity. Preliminary results suggest glutamatergic transmission is overtly normal in DuspX-KO mice compared with WT [...]