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Biochemical, cellular and physiological alterations of the glutamatergic synapse in a trisomic mouse model of Down syndrome

Along this project, we have explored the alterations of the glutamatergic synapse of the Ts65Dn mouse model of Down syndrome. We have fully characterized the proteomic and phosphoproteomic profile of subsynaptic fractions of the hippocampi of trisomic mice. Along this approach, we characterized candidate residues of the glutamate ionotropic receptors that are altered in trisomic […]

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